User:RelentessRecusant/SANT1

SANT1 (" S moothened Ant agonist 1 "), IUPAC name (E)-4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene)piperazin-1-amine, is a specific small-molecule chemical inhibitor of Smoothened (Smo), strongly inhibiting sonic hedgehog (Shh) signaling. It has an IC50 of 20-30 nM in various hedgehog cellular assays, such as Shh-luciferase assay. SANT1 is a specific inhibitor of Smoothened, and demonstrates competition with cyclopamine for binding to the Smo receptor.

It was originally synthesized and characterized by Chen et. al in 2002 at the Johns Hopkins University School of Medicine and the Howard Hughes Medical Institute.