User:RelentlessRecusant/KAAD-Cyclopamine

KAAD-Cyclopamine ("3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine"), otherwise known as Cyclopamine-KAAD, IUPAC name N-[2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8,11,11a-decahydrobenzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4'-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide, is a specific small-molecule chemical inhibitor of Smoothened (Smo) and sonic hedgehog (Shh) intracellular signaling.

It is a synthetic structurally-related derivative of cyclopamine, a structurally-complex natural product that is steroid alkaloid teratogen derived from the plant Veratrum species.

It was originally synthesized and characterized by Taipale et. al in 2000 at the Johns Hopkins University School of Medicine, the Stanford University School of Medicine, and the Howard Hughes Medical Institute.