User:RelentlessRecusant/Bicuculline

Bicuculline, IUPAC name (R)-6-((S)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuro[4,5-d][1,3]dioxol-8(6H)-one, is an alkaloid natural product that is a small-molecule chemical inhibitor of gamma-aminobutyric acid type A receptors (GABAAR), IC50 = 3 μM for inhibitory activity.

Its blockade of GABAAR activity leads to significant promotion of embryonic stem (ES) and neural stem (NSC) cell proliferation and cell-cycle progression.