User:RelentlessRecusant/A-83-01

A-83-01, IUPAC name 3-(6-Methylpyridin-2-yl)-1-phenylthiocarbamoyl-4-quinolin-4-ylpyrazole, is a small-molecule chemical inhibitor of Type I TGFβ receptor tyrosine kinases (RTK), specifically inhibiting receptors of the ALK5 family (ALK4, ALK5, and ALK7) and preventing the transmission of a number of biological signals, including Activin A signals, Nodal signalins, and TGFβ. A-83-01 was synthesized from a 4-(quinolin-4-yl)-substituted pyrazole scaffold.