User:RelentlessRecusant/Hh-Ag1.5

Hh-Ag1.5 (" H edge h og Ag onist 1.5 "), IUPAC name 3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide, is a small-molecule chemical agonist of Smoothened (Smo) receptor and is an activator of sonic hedgehog (Shh) signaling. It is structurally related to other Smo agonists, collectively Hh-Ag1.1, Hh-Ag1.2, Hh-Ag1.3, Hh-Ag1.4, and SAG (" S moothened Ag onist").

Hh-Ag1.5 was derived from structure-activity relationship (SAR) studies of an initial synthetic hit compound, "Hh-Ag1.1", and is a difluoronated and methylated derivative, with chemical optimization resulting in a compound with thousandfold-elevated activity and an IC50 = 1 nM for agonist activity.

It was originally synthesized and characterized by Frank-Kamenetsky et. al in 2002 at Curis, Inc., a novel biotechnology company based in Cambridge, Massachusetts, with collaborations from the Columbia University, College of Physicians and Surgeons at New York.