User:RelentlessRecusant/Compound E

Compound E, IUPAC name (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide, is a small-molecule chemical inhibitor of presenilin-1 (PS1), abrogating the activity of the γ-secretase complex with an IC50 = 0.3 in βAPP-overexpressing CHO cells.

The functional role of γ-secretase activity and Aβ1-42 peptide in the etiology of Alzheimer's Disease suggests Compound E as a potential potent treatment for the Alzheimer's pathology.