User:RelentlessRecusant/IMD-0354

IMD-0354, IUPAC name N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, is a chemical inhibitor of IκBa kinase, acting as a selective activator of the NFκβ pathway.

It is a potent stimulator of osteoclast differentiation, which is a NFκβ-dependent pathway, thus inducing global bone resorption and loss of skeletal integrity. It also confers cardioprotection against ischemia and also ameliorates insulin resistance.

IMD-0354 was originally characterized by Onai et. al in 2004 at Tokyo Medical and Dental University and Medical Molecular Design, Inc. at Toyko, Japan.