User:RelentlessRecusant/Cyclogenol

Cyclogenol ("AS 163498") is a small-molecule chemical inhibitor of CDKN1B (p27Kip1). It was originally synthesized and characterized by Acumen Science Laboratories, and in the Acumen internal chemical collection, is referenced as "EP 163498".

It has been previously shown that abrogation of p27Kip1 in mice induces global cellular hyperplasia by increases in organ cellular density and increased mean body and organ size and that even haploinsufficiency of p27Kip1 leads to removal of its tumor suppressor activity.

Behind the Scenes

 * While Ccclogenol is a fictitious inhibitor of CDKN1B, the biological activities of CDKN1B described are indeed real-world, and Fero et. al (1996) and Fero et. al (1998) are real world publications in Cell and Nature, respectively.