User:RelentlessRecusant/Small molecule control over the activity of ultraconserved genetic elements in sentient species

Browning et. al (2605). . Nature Chemical Biology (2609): 34-40.



1UNSC Office of Naval Intelligence, Department of Biological Warfare, Asphodel Meadows, 47 Ursae Majoris System 2UNSC Office of Naval Intelligence, Program in Human Configuration, Asphodel Meadows, 47 Ursae Majoris System 3Acumen Science Laboratories, Department of High-Throughput Screening, Earth, Sol System

Abstract

Previous reports have extensively debated over the evolutionary purpose of ultraconservation of genetic elements in sentient species (Escobar et. al, 2555, Nature; Loh et. al, 2556, Nature; Miyagi et. al, 2557, Nature; Loh et. al, 2557, Nature; Loh et. al, 2558, Nature Neuroscience) because of a lack to activate these elements in their native chromosomal locus. Here, through screening of chemical libraries and synthetic chemistry, we describe the development of a series of chemical compounds that activate endogenous ultraconserved genetic elements, thus providing a novel tool for investigators seeking to interrogate the endogenous roles of these elements.