User:RelentlessRecusant/Ultraconserved sequences in sentient species are not ultraselected and are not active in development nor the adult

Miyagi et. al (2556). . Nature (3081): 815-823.



1Joslin Diabetes Center, Department of Medicine and Harvard Medical School, Earth, Sol System 2SierraCell Inc., Department of Personalized Genomics, Thebes, Alpha Centauri System

Abstract

A plethora of recent reports (Escobar et. al, 2555, Nature; Loh et. al, 2556, Nature) have suggested that genomic sequences ultraconserved exclusively amongst sentient species confers sentience upon these species. Consistent with the previous observation that microdeletion of some of these sequences in the murine genome confers no deleterious phenotype, here, with individual high-resolution genomic sequences, that humans with chromosomal deletions of these conserved sequences also do not display a deleterious phenotyping, suggesting that conservation of these regions is not ultraselected for. Furthermore, genome-wide transcriptome mapping shows that throughout development, neonatal life, and adult life, these sequences are never transcribed in M. musculus, demonstrating that they likely have no biological significance in the living animal.