User:RelentlessRecusant/QS11

QS11, IUPAC name (S)-2-(9-(biphenyl-4-ylmethyl)-2-(2,3-dihydro-1H-inden-5-yloxy)-9H-purin-6-ylamino)-3-phenylpropan-1-ol, is a small-molecule chemical inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) that synergizes with recombinant Wnt3a in the activation of the canonical Wnt/β-catenin signaling pathway. . It was originally concieved from the high-throughput screening of a 100,000 compound library of heterocycles against a low-content luciferase-based assay analysis system, where 2,6,9-trisubstituted purine derivatives were identified through chemical hierarchical clustering of compound hits. Focused structure-activity relation (SAR) studies resulted in the synthesis of a derivative, QS11, which demonstrated the most potent activity.

QS11 was originally synthesized and characterized by Zhang et. al in 2006 at the Scripps Research Institute in California, United States of America.